A Rapid Experimental Polar Surface Area (EPSA) Assay

Understanding Drug Bioavailability with Polar Surface Area

Polar surface area, often synonymous with hydrogen bond availability, stands as a pivotal physical property in comprehending drug bioavailability. Traditionally, a molecule's Topological Polar Surface Area (TPSA) serves as a proxy for this property, aiding in the ranking of similar molecules. However, TPSA sometimes falls short in distinguishing compounds undergoing conformational changes in solution.